Molecular and cellular dynamics of the developing human neocortex

Authors

Li Wang, Cheng Wang, Juan A. Moriano, Songcang Chen, Guolong Zuo, Arantxa Cebrián-Silla, Shaobo Zhang, Tanzila Mukhtar, Shaohui Wang, Mengyi Song, Lilian Gomes de Oliveira, Qiuli Bi, Jonathan J. Augustin, Xinxin Ge, Mercedes F. Paredes, Eric J. Huang, Arturo Alvarez-Buylla, Xin Duan, Jingjing Li & Arnold R. Kriegstein

Citation

Wang, L., Wang, C., Moriano, J.A. et al. Molecular and cellular dynamics of the developing human neocortex. Nature (2025).

https://doi.org/10.1038/s41586-024-08351-7

Summary

The study creates a single-cell multi-omic atlas of human neocortical development, identifying tripotential intermediate progenitors that generate GABAergic neurons, oligodendrocyte precursors, and astrocytes, and shows glioblastoma cells share their transcriptomic features. It also links second-trimester intratelencephalic neurons to increased autism risk.

Nature Collection

Wang et al., Nature

Resource Name	Resource URL	Description
NeMO archive	https://assets.nemoarchive.org/dat-oilf74w	Data download: 988 files of raw and aligned snMultiome data.
BIL archive	https://doi.org/10.35077/g.1156	Data download: Raw and pre-processed MERFISH data.
Interactive Portal	https://cell.ucsf.edu/snMultiome/	Data exploration: Browse chromatin accessibility and MERSCOPE data.
CELLxGENE	https://cellxgene.cziscience.com/collections/19c5-41de-8cfe-44710fbada73	Data visualization: Explore single cell data in CELLxGENE.
Dryad	https://doi.org/10.5061/dryad.2280gb	Data download: 135.22 GB files of processed data.
Project Page	https://knowledge.brain-map.org/data/SFNQPMODRGGFBZB	Project Page in the BICAN Data Catalog.