Cell types of the basal ganglia: a multimodal view from the BICAN package

The basal ganglia are a set of brain structures involved in movement, learning, and adaptive behavior, and are implicated in many neurological and psychiatric disorders. Members of the BRAIN Initiative Cell Atlas Network (BICAN) Consortium have applied a variety of single cell,   spatial transcriptomic, and epigenomic technologies to map the cellular and molecular organization of these regions in the human, macaque, mouse, and marmoset brain. This effort has produced a taxonomy of cell types conserved across human, non-human primate, and mouse brains, that provide an essential reference for integrating information about neural circuits and disease states into our understanding of the brain.

This webinar presents results of the basal ganglia effort, with 26 papers recently published in Cell and Cell Press journals. The selection of studies featured in this webinar are focused on the cross-species consensus cell and spatial atlases of the primate basal ganglia, epigenomic atlas, variation across human populations, and findings related to autism.

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