Conservation and alteration of mammalian striatal interneurons

Authors

Emily K. Corrigan, Michael DeBerardine, Aunoy Poddar, Miguel Turrero García, Sean de la O, Siting He, Harsha Sen, Mariana Duhne, Shanti Lindberg, Menygi Song, Matthew T. Schmitz, Karen Sears, Ricardo Mallarino, Joshua D. Berke, Corey C. Harwell, Mercedes F. Paredes, Fenna M. Krienen, Alex A. Pollen

Citation

Corrigan, E., et al. Conservation and alteration of mammalian striatal interneurons. Nature (2025).

https://doi.org/10.1038/s41586-025-09592-w

Summary

We survey gene expression from 10 mammalian species, spanning 160 million years of divergence, and discover that TAC3 interneurons, previously thought to be a primate specific population, instead represent a conserved, ancestral population with modified gene expression and distribution throughout evolution. This finding suggests that brain evolution among mammals occurs through fate refinement of initial classes during development, rather than the generation of entirely novel populations.

Nature Collection

Corrigan et al., Nature

Resource Name	Resource URL	Description
Hotspot Code	https://github.com/YosefLab/Hotspot	Code Repository: hotspots v1.1.1 code for identifying informative genes and gene modules in a single-cell dataset.
Github scripts and annotation files	https://github.com/mdeber/Corrigan2	Code Repository: python multi-species analysis code.