Continuous cell-type diversification in mouse visual cortex development

Authors

Yuan Gao, Cindy T. J. van Velthoven, Changkyu Lee, Emma D. Thomas, Rémi Mathieu, Angela P. Ayala, Stuard Barta, Darren Bertagnolli, Jazmin Campos, Trangthanh Cardenas, Daniel Carey, Tamara Casper, Anish Bhaswanth Chakka, Rushil Chakrabarty, Megan Chiang, Lindsey Ching, Michael Clark, Marie J. Desierto, Rebecca Ferrer, Jessica Gloe, Jeff Goldy, Nathan Guilford, Junitta Guzman, Carliana R. Halterman, Samantha D. Hastings, Daniel Hirschstein, Windy Ho, Katelyn James, Zoe Juneau, Naomi Martin, Rachel McCue, Emma Meyerdierks, Amanda C. Mitchell, Josh S. Nagra, Beagan Nguy, Thuc Nghi Nguyen, Paul Olsen, Alana A. Oyama, Nick Pena, Jacob Quon, Qingzhong Ren, Augustin Ruiz, Nadiya V. Shapovalova, Josef Sulc, Amy Torkelson, Alex Tran, Herman Tung, Nasmil Valera Cuevas, Justin Wang, Jeanelle Ariza, Delissa A. M. McMillen, Jack Waters, Michael Kunst, Kara Ronellenfitch, Boaz Levi, Michael J. Hawrylycz, Chelsea Pagan, Nick Dee, Kimberly A. Smith, Bosiljka Tasic, Zizhen Yao, Hongkui Zeng

Citation

Gao, Y., et al. Continuous cell-type diversification in mouse visual cortex development. Nature (2025).

https://doi.org/10.1038/s41586-025-09644-1

Summary

This study presents a comprehensive single-cell transcriptomic and epigenomic atlas of mouse visual cortex development from embryonic to adult stages (E11.5–P56). The analysis reconstructs developmental trajectories and reveals continuous diversification of excitatory, inhibitory, and non-neuronal cell types, driven by coordinated changes in gene expression and chromatin accessibility across stages of cortical maturation.

Nature Collection

Gao et al., Nature

Resource Name	Resource URL	Description
NeMO archive	https://assets.nemoarchive.org/dat-5y9m0n	Data download: Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development. 693 files (14,052 GB) of data, including raw data.
Data and Taxonomy	https://doi.org/10.82150/e9nh-3537	Data download: Mouse visual cortex development Taxonomy v1.0 with processed data.