Spatial dynamics of brain development and neuroinflammation

Authors

Di Zhang, Leslie A Rubio Rodríguez-Kirby, Yingxin Lin, Wenqi Wang, Mengyi Song, Li Wang, Lijun Wang, Shigeaki Kanatani, Tony Jimenez-Beristain, Yonglong Dang, Mei Zhong, Petra Kukanja, Shuozhen Bao, Shaohui Wang, Xinyi Lisa Chen, Fu Gao, Dejiang Wang, Hang Xu, Cong Ma, Xing Lou, Yang Liu, Jinmiao Chen, Nenad Sestan, Per Uhlén, Arnold Kriegstein, Hongyu Zhao, Gonçalo Castelo-Branco, and Rong Fan

Citation

Zhang, D., et al. Spatial dynamics of brain development and neuroinflammation. Nature (2025).

https://doi.org/10.1038/s41586-025-09663-y

Summary

Spatial tri-omics unveiled spatiotemporal dynamics of brain development around birth and of neuroinflammation in a mouse de/remyelination model. In particular, our data highlight coordination between different brain regions during developmental myelination in the corpus callosum and microglial activation at distal sites in focal demyelination.

Nature Collection

Zhang et al., Nature

Resource Name	Resource URL	Description
NeMO archive	https://assets.nemoarchive.org/col-1w5kt2k	Data download: raw omics data.
GEO	https://www.ncbi.nlm.nih.gov/geo/query/acc=GSE92023	GEO Omnibus: Gene expression data download
Data portal	https://spatial-omics.yale.edu/	Data exploration: Spatial epigenome–transcriptome–proteome mapping of mouse and human brain development and neuroinflammation.
Codex data	https://zenodo.org/records/17121652	Data download: Codex data released in Zenodo.
atlas of the adolescent mouse brain	http://mousebrain.org/adolescent/dev	Data download: Landing page with links to data availability for raw sequ Previous Next The Brain Cell Data Center (BCDC) at the Allen Institute for Brain Science provides a foundational community resource on cell types in the mammalian brain by sharing the integrated data, tools, and knowledge produced by the BRAIN Initiative Cell Atlas Network (BICAN). Terms of Use Privacy Policy Contact Us or Subscribe © 2023 by Allen Institute. All Rights Reserved.