Transcriptomic and spatial organization of telencephalic GABAergic neurons

Authors

Cindy T. J. van Velthoven, Yuan Gao, Michael Kunst, Changkyu Lee, Delissa McMillen, Anish Bhaswanth Chakka, Tamara Casper, Michael Clark, Rushil Chakrabarty, Scott Daniel, Tim Dolbeare, Rebecca Ferrer, Jessica Gloe, Jeff Goldy, Junitta Guzman, Carliana Halterman, Windy Ho, Mike J. Huang, Katelyn James, Rachel McCue, Beagan Nguy, Trangthanh Cardenas, Kara Ronellenfitch, Emma D. Thomas, Amy Torkelson, Chelsea M. Pagan, Lauren Kruse, Nick Dee, Lydia Ng, Jack Waters, Kimberly A. Smith, Bosiljka Tasic, Zizhen Yao, Hongkui Zeng

Citation

van Velthoven, C.T.J., et al. The transcriptomic and spatial organization of telencephalic GABAergic neuronal types. Nature (2025).

https://doi.org/10.1038/s41586-025-09296-1

Summary

This study provides a comprehensive transcriptomic and spatial atlas of GABAergic neuron types across the mouse telencephalon, integrating data from developing and adult brains. The resulting hierarchical taxonomy reveals more than 1,000 distinct cell clusters, uncovering how spatial organization, developmental origins, and postnatal diversification shape the remarkable diversity of telencephalic inhibitory neurons.

Nature Collection

van Velthoven et al., Nature

Resource Name	Resource URL	Description
NeMO archive	https://assets.nemoarchive.org/dat-zqurqvh	Data download: The transcriptomic and spatial organization of telencephalic GABAergic neuronal types. 679 files (22.24 GB).
BIL archive	https://doi.org/10.35077/g.610	Data download: Mouse whole-brain transcriptomic cell type atlas – MERSCOPE V1